I utilise multiple combo-boxes on a form, where results from the first combo-box determine what is available in the next combo-box, works brilliantly.
However I decided to group my business objects in order to search for related info, ever since I grouped my filters in the combo-box do not work, I even double checked the filters on the combo-boxes after I created the group.
Version 8.1 (Build 2461) running on Windows Server 2012 R2 Standard